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GLP-1 receptor agonists for major cardiovascular and kidney outcomes in type 1 diabetes

To examine whether activation of this signaling pathway may mimic the acute effects of Ex-4c, we applied 10 M forskolin (an adenylate cyclase activator) or 500 M 8-Br-cAMP (a PKA activator), both of which activate the PKA signaling pathway, to the bath solutions